Mountainair is located on US-60 about 40 miles east of I-25. The intersection with I-25 lies between Belen and Socorro, about 50 miles south of Albuquerque. US-60 continues east into Southeast New Mexico, passing through Fort Sumner and Clovis.
From the north, a more scenic and longer trip from Albuquerque is to take I-40 to Tijeras, then take NM-337 south to NM-55 south, which brings you into Mountainair through several small settlements. This route passes by the eastern side of the Manzano Mountains.